MUSCLE (3.7) multiple sequence alignment NC_002645_HCoV-229E_inf-1_nsp2_6 --NVTYTDQYLCGADGKPVMS--------------EDLWQFVDHFGENEE--IIINGHTY NC_005831_HCoV-NL63_AmsterdamI_n --SVVFVDKYMCGFDGKPVLP--------------KNMWEFRDYFNNNTD-SIVIGGVTY NC_002306_TGEV_PUR46-MAD_nsp2_63 -RGAIYVDQYMCGADGKPVIE-----------------GDFKDYFGDEDI--IEFEGEEY NC_003436_PEDV_CV777_nsp2_627..2 --NIVPVDQYMCGADGKPVLQ--------------ESEWEYTDFFADSEDGQLNIAGITY DQ811787_PRCV_ISU-1_nsp2_628..29 -RGVIYVDQYMCGADGKPVIE-----------------GDFKDYFGDEDI--IEFEGEEY AY994055_FIPV_79-1146_nsp2_641.. ---AIYVDQYMCGADGKPVIE-----------------GEFKDYFGDEDV--IIYEGEEY NC_009657_BtCoV-G1_BtCoV/512/200 --TTIPVDQFMCGADGAPVIQ--------------EGDWTFMDYFQDSNQ--FTLNGITY EF203064_Bat-CoV-HKU2_HKU2/GD/43 --DVVPVDNYMCGADGKPAVP--------------SEQWSFVEHFDDDTD-EITVNGVTF NC_005147_HCoV-OC43_OC43_nsp2_94 VKPLLYVDQYGCDYTGSLADGLEAY-----ADKTLQEMKALFPTWSQELL-------FDV NC_006577_CoV-HKU1A_N1_nsp2_872. IKPVLFVDQYGCDYSGKLADCLQAY-----GHYSLQDMRQKQSVWLANCD-------FDI AY884001_CoV-HKU1B_N2_nsp2_866.. IKPVLFVDQYGCDYSGKLADCLQAY-----GHYSLQDMRQKQSVWLANCD-------FDI DQ339101_CoV-HKU1C_N5_nsp2_866.. IKPVLFVDQYGCDYSGKLADCLQAY-----GHYSLQDMRQKQSVWLANCD-------FDI NC_003045_BCoV_BCoV-ENT_nsp2_949 VKPLLYVDQYGCDYTGGLADGLEAY-----ADKTLQEMKALFPIWSQELP-------FDV NC_001846_MHV_MHV-A59_nsp2_951.. VKPILFVDQYGCDYTGCLAKGLEDY-----GDLTLSEMKELFPVWRDSLD-------SEV NC_007732_PHEV_VW572_nsp2_949..2 VKPLLYVDQYGCDYTGGLADGLEAY-----ADKTLQEMKALFPIWSQELP-------FDV EF424621_AntelopeCoV_US/OH1/2003 VKPLLYVDQYGCDYTGGLADGLEAY-----ADKTLQEMKALFPIWSQELP-------FDV EF424622_GiCoV_US/OH3-TC/2006_ns VKPLLYVDQYGCDYTGGLADGLEAY-----ADKTLQEMKALFPIWSQELP-------FDV NC_004718_SARS-human_Tor2_nsp2_8 AVTRYVDNNF-CGPDGYPLDCIKDFLA--RAGKSMCTLSEQLDYIESKRG-VYCCRDHEH AY304488_SARS-civet_SZ16_nsp2_79 AVTRYVDNNF-CGPDGYPLDCIKDFLA--RAGKSMCTLSEQLDYIESKRG-VYCCRDHEH NC_009694_SARS-bat_HKU3-1_nsp2_8 VVTRYVDNNF-CGPDGYPLECIKDFLA--RAGKSMCTLSEQLDYIESKRG-VYCCREHEH AY545919_SARS-badger_CFB/SZ/94/0 AVTRYVDNNF-CGPDGYPLDCIKDFLA--RAGKSMCTLSEQLDYIESKRG-VYCCRDHEH NC_009019_Bat-CoV-HKU4_B04f --DCIPIDQYMCGKNGKPIADYAKIVAK-EGLTTLADIEVDVKSRMDSDR-FIVLNKKLY NC_009020_Bat-CoV-HKU5_LMH3f --DFTPIDQYMCGKNGKPIAEFAALMAS-EGITKLADVEAEVKSRTDSDR-YIVFKNKLY NC_009021_Bat-CoV-HKU9_BF_005I --DVYLSDQYGFDNNGILVEPVMKLLGVIKSDFTLEQLLAALGKYRTEDG--YDLPDGYV NC_001451_IBV_Beaudette_nsp2_529 --MASSLKQGVSPKPRDVILV---------SKDIPEQLCDALFFYTSHNP-------KDY AY646283_IBV-partridge_Partridge --MASSLKQGVSSQNQRSVVLV--------AKDIPDQLRDALFFYTSHNP-------KDY AY641576_IBV-peafowl_Peafowl/GD/ --MASSLKQGVSPKLRDVILV---------SKDIPEQLCDALFFYTSHNP-------KDY .: NC_002645_HCoV-229E_inf-1_nsp2_6 VCAWLTKR---------KPLDYKR-QNNLAIEEIEYVHGDALHTLRNGSVLEMAKEVKTS NC_005831_HCoV-NL63_AmsterdamI_n QLAWDVIR---------KDLSYEQ-QNVLAIESIHYL-GTTGHTLKSGCKLTNAKPPKYS NC_002306_TGEV_PUR46-MAD_nsp2_63 HCAWTTVR---------DEKPLNQ-QTLFTIQEIQYN-LDIPHKLPNCATRHVAPPVKKN NC_003436_PEDV_CV777_nsp2_627..2 VKAWIVER---------SDVSYAS-QNLTSIKSITYC-STYEHTFLDGTAMKVARTPKIK DQ811787_PRCV_ISU-1_nsp2_628..29 HCAWTTVR---------DEKPLNQ-QTLFTIQEIQYN-LDIPHKLPNCATRHVAPPVKKN AY994055_FIPV_79-1146_nsp2_641.. HCAWLTVR---------DEKPLWQ-QTLLTIREIQYN-LDIPHKLPNCAIREVAPPVKKN NC_009657_BtCoV-G1_BtCoV/512/200 VKAWDVDR---------KPNDYAK-QNVTCIRRITYI-TDHRHVLADGTTMKTARHPKVN EF203064_Bat-CoV-HKU2_HKU2/GD/43 RHAWNTVR---------ADDPYEK-QGLLSIKFIEYI-SNVPHKLPNGSVLGVAGTPKKR NC_005147_HCoV-OC43_OC43_nsp2_94 IVAWHVVR---------DPRYVMRLQSAATIRSVAYV-ANPTEDLCDGSV-----VIKEP NC_006577_CoV-HKU1A_N1_nsp2_872. VVAWHVVR---------DSRFVMRLQTIATICGIKYV-AQPTEDVVDGDV-----VIREP AY884001_CoV-HKU1B_N2_nsp2_866.. VVAWHVVR---------DSRFVMRLQTIATICGIKYV-AQPTEDVVDGAV-----VIREP DQ339101_CoV-HKU1C_N5_nsp2_866.. VVAWHVVR---------DSRFVMRLQTIATICGIKYV-AQPTEDVVDGDV-----VIREP NC_003045_BCoV_BCoV-ENT_nsp2_949 TVAWHVVR---------DPRYVMRLQSASTIRSVAYV-ANPTEDLCDGSV-----VIKEP NC_001846_MHV_MHV-A59_nsp2_951.. LVAWHVDR---------DPRAAMRLQTLATVRCIDYV-GQPTEDVVDGDV-----VVREP NC_007732_PHEV_VW572_nsp2_949..2 TVAWHVVR---------DPRYVMRLQSASTIRSVAYV-ANPTEDLCDGSV-----VIKEP EF424621_AntelopeCoV_US/OH1/2003 TVAWHVVR---------DPRYVMRLQSASTIRSVAYV-ANPTEDLCDGSV-----VIKEP EF424622_GiCoV_US/OH3-TC/2006_ns TVAWHVVR---------DPRYVMRLQSASTIRSVAYV-ANPTEDLCDGSV-----VIKEP NC_004718_SARS-human_Tor2_nsp2_8 EIAWFTER---------SDKSYEH-QTPFEIKSAKKF-DTFKGECPKFVF-----PLNSK AY304488_SARS-civet_SZ16_nsp2_79 EIAWFTER---------SDKSYEH-QTPFEIKSAKKF-DTFKGECPKFVF-----PLNSK NC_009694_SARS-bat_HKU3-1_nsp2_8 EIVWFTER---------SEKSYEH-QTPFEIKSAKKF-DTFKGECPKFVF-----PLNSK AY545919_SARS-badger_CFB/SZ/94/0 EIAWFTER---------SDKSYEH-QTPFEIKSAKKF-DTFKGECPKFVF-----PLNSK NC_009019_Bat-CoV-HKU4_B04f RVVWNVTR---------RNVPYPK-QTAFTIVSVVQC--DDKDSVPEHTF-----TIGSQ NC_009020_Bat-CoV-HKU5_LMH3f RIVWNVQR---------KDVAYSK-QSAFTMNSIVQL--DTMEDVPRHSF-----TIGSE NC_009021_Bat-CoV-HKU9_BF_005I KVAIKVGR---------KAVPVLK-QSIFTVVGVT------EQLVPGYYY-----PFSTS NC_001451_IBV_Beaudette_nsp2_529 ADAFAVRQKFDRSLQTGKQFKFETVCGLFLLKGVDKI------------------TPGVP AY646283_IBV-partridge_Partridge ADAFAFKRKFDRNLGAGKQFKFETVCGPFFLKGVDKV------------------TPGVP AY641576_IBV-peafowl_Peafowl/GD/ ADAFAVRQKFDRNLQTGKQFKFETVCGLFLLKGVDKI------------------TPGVP . . : NC_002645_HCoV-229E_inf-1_nsp2_6 SKVV-LSDALDKLYKVFGSP--VMTNGSNILEAFTKPVFISALVQCTCGTKSWSVGDWTG NC_005831_HCoV-NL63_AmsterdamI_n SKVV-LSGEWNAVYRAFGSP--FITNGMSLLDIIVKPVFFNAFVKCNCGSESWSVGAWDG NC_002306_TGEV_PUR46-MAD_nsp2_63 SKIV-LSEDYKKLYDIFGSP--FMGNGDCLSKCFDTLHFIAATLRCPCGSESSGVGDWTG NC_003436_PEDV_CV777_nsp2_627..2 KNVV-LSEPLATIYREIGSP--FVDNGSDARSIIRRPVFLHAFVKCKCGSYHWTVGDWTS DQ811787_PRCV_ISU-1_nsp2_628..29 SKIV-LSEDYKKLYDIFGSP--FMGNGDCLSKCFDTLHFIAATLRCPCGSESSGVGDWTG AY994055_FIPV_79-1146_nsp2_641.. SKVV-LSEEYRKLYDIFGSP--FMGNGDSLNTCFDSLHFIAATLKCPCGAESSGVGDWTG NC_009657_BtCoV-G1_BtCoV/512/200 KSVV-LDSPFDQIYKEVGSP--FMGNGSTFVEMLKDPAFFHALITCECGRSEWTVGDWKG EF203064_Bat-CoV-HKU2_HKU2/GD/43 KAVV-LDEKYSKLYDACGVP--FVTNGKSISEVVTKPLFLHALVECKCGNESWTVGDWTG NC_005147_HCoV-OC43_OC43_nsp2_94 VHVYADDSIILRQYNLVDIMSHFYMEADTVVNA-----FYGVALK-DCGFVMQF-----G NC_006577_CoV-HKU1A_N1_nsp2_872. VHLLSADAIVLKLPSLMKVM--THMDDFSIKS------IYNVDL-CDCGFVMQY-----G AY884001_CoV-HKU1B_N2_nsp2_866.. VHLLSADAIVLKLPSLMKVM--THMDDFSIKS------IYNVDL-CDCGFVMQY-----G DQ339101_CoV-HKU1C_N5_nsp2_866.. VHLLSADAIVLKLPSLMKVM--THMDDFSIKS------IYNVDL-CDCGFVMQY-----G NC_003045_BCoV_BCoV-ENT_nsp2_949 VHVYADDSIILRQHNLVDIMSCFYMEADAVVNA-----FYGVDLK-DCGFVMQF-----G NC_001846_MHV_MHV-A59_nsp2_951.. AHLLAANAIVKRLPRLVETM--LYTDSSVTE-------FCYKTKLCECGFITQF-----G NC_007732_PHEV_VW572_nsp2_949..2 VHVYADDSIILRQHNLVDIMSCFYMEADAVVNA-----FYGVDLK-DCGFVMQF-----G EF424621_AntelopeCoV_US/OH1/2003 VHVYADDSIILRQHNLVDIMSCFYMEADAVVNA-----FYGVDLK-DCGFVMQF-----G EF424622_GiCoV_US/OH3-TC/2006_ns VHVYADDSIILRQHNLVDIMSCFYMEADAVVNA-----FYGVDLK-DCGFVMQF-----G NC_004718_SARS-human_Tor2_nsp2_8 VKVI-QPRVEKK--KTEGFM--GRIRS-----------VYPVASPQECNNMHLS-----T AY304488_SARS-civet_SZ16_nsp2_79 VKVI-QPRVEKK--KTEGFM--GRIRS-----------VYPVASPQECNNMHLS-----T NC_009694_SARS-bat_HKU3-1_nsp2_8 VKVI-QPRVEKK--KTEGFM--GRIRS-----------VYPVATPQECNDMHLS-----T AY545919_SARS-badger_CFB/SZ/94/0 VKVI-QPRVEKK--KTEGFM--GRIRS-----------VYPVASPQECNNMHLS-----T NC_009019_Bat-CoV-HKU4_B04f ILMV-SPLKATN-NKNFNLK--QRLLYT----------FYGKDAVQQPGYIYHS-----A NC_009020_Bat-CoV-HKU5_LMH3f IQVI-APSTAVQANGHLNLK--QRLLYA----------FYGKQAVSEPNYIYHS-----A NC_009021_Bat-CoV-HKU9_BF_005I SVVE-HTKPTR-----GGPV--GKTVEA---------VMLSLYGTNNYNPATPV-----A NC_001451_IBV_Beaudette_nsp2_529 AKVLKATSKLADLEDIFGVS--PLARK------------YRELLKTACQWSLTV-----E AY646283_IBV-partridge_Partridge AKVLKATSKLADLEDIFGVS--PFARK------------YRELLKTACQWSLTV-----D AY641576_IBV-peafowl_Peafowl/GD/ AKVLKATSKLADLEDIFGVS--PFARK------------YRELLKTACQWSLTV-----E : NC_002645_HCoV-229E_inf-1_nsp2_6 FKSSCCNVISNKLC-----VVPGNVKPGDAVITTQQAGAGIKY--FCGMTLKFVANIE-- NC_005831_HCoV-NL63_AmsterdamI_n YLSSCCGTPAKKLC-----VVPGNVVPGDVIITSTSAGCGVKY--YAGLVVKHITNIT-- NC_002306_TGEV_PUR46-MAD_nsp2_63 FKTACCGLSGKVKG-----VTLGDIKPGDAVVTSMSAGKGVKF--FANCVLQYAGDVE-- NC_003436_PEDV_CV777_nsp2_627..2 YVSTCCGFKCKPVL-----VASCSAMPGSVVVTRAGAGTGVKY--YNNMFLRHVADID-- DQ811787_PRCV_ISU-1_nsp2_628..29 FKTACCGLSGKVKG-----VTLGDIKPGDAVVTSMSAGKGVKF--FANCVLQYAGDVE-- AY994055_FIPV_79-1146_nsp2_641.. FKTACCGLHGKVKG-----VTLGAVKPGDAIVTSMSAGKGVKF--FANSVLQYAGDVE-- NC_009657_BtCoV-G1_BtCoV/512/200 YNSLCCNIKCKPIT-----IVTPKAVPGAVVITKAGIGAGLKC--YNNVFLKHIIDLVVP EF203064_Bat-CoV-HKU2_HKU2/GD/43 FKTTCCGVTGKVIT-----LAVGDVTPGDIVFTTPGAGKGTKF--FCGLVLTFVDTLE-- NC_005147_HCoV-OC43_OC43_nsp2_94 YID-CEQDSCDFKG-----WIPGNMIDGFACTT-----CGHVY--EVGDLIAQSSGVL-- NC_006577_CoV-HKU1A_N1_nsp2_872. YVD-CFNDNCDFYG-----WVSGNMMDGFSCPL-----CCTVY--DSSEVKAQSSGVI-- AY884001_CoV-HKU1B_N2_nsp2_866.. YVD-CFNDNCDFYG-----WVSGNMMDGFSCPL-----CCTVY--DSSEVKAQSSGVI-- DQ339101_CoV-HKU1C_N5_nsp2_866.. YVD-CFNDNCDFYG-----WVSGNMMDGFSCPL-----CCTVY--DSSEVKAQSSGVI-- NC_003045_BCoV_BCoV-ENT_nsp2_949 YID-CEQDLCDFKG-----WVPGNMIDGFACTT-----CGHVY--ETGDLLAQSSGVL-- NC_001846_MHV_MHV-A59_nsp2_951.. YVD-CCGDTCDFRG-----WVAGNMMDGFPCPG-----CTKNY--MPWELEAQSSGVI-- NC_007732_PHEV_VW572_nsp2_949..2 YID-CEQDLCDFKG-----WVPGNMIDGFACTT-----CGHVY--ETGDLLAQSSGVL-- EF424621_AntelopeCoV_US/OH1/2003 YID-CEQDLCDFKG-----WVPGNMIDGFACTT-----CGHVY--ETGDLLAQSSGVL-- EF424622_GiCoV_US/OH3-TC/2006_ns YID-CEQDLCDFKG-----WVPGNMIDGFACTT-----CGHVY--ETGDLLAQSSGVL-- NC_004718_SARS-human_Tor2_nsp2_8 LMK-C--NHCDEVS-----WQTCDFLK-ATCEH-----CGTENLVIEG---PTTCGYL-- AY304488_SARS-civet_SZ16_nsp2_79 LMK-C--NHCDEVS-----WQTCDFLK-ATCEH-----CGTENLVIEG---PTTCGYL-- NC_009694_SARS-bat_HKU3-1_nsp2_8 LMK-C--NHCDEVS-----WQTCDFLK-ATCEQ-----CGTENLVCEG---PTTCGYL-- AY545919_SARS-badger_CFB/SZ/94/0 LMK-C--NHCDEVS-----WQTCDFLK-ATCEH-----CGTENLVIEG---PTTCGYL-- NC_009019_Bat-CoV-HKU4_B04f YVD-C--NACGRGT-----WCTGNAIQGFACD------CGANY--SANDVDLQSSGLV-- NC_009020_Bat-CoV-HKU5_LMH3f YVD-C--TSCGKGS-----WLTGNAVQGFACD------CGAHY--CANDVDLQSSGLV-- NC_009021_Bat-CoV-HKU9_BF_005I RLK-C--SYCDYYG-----WTPLKDIGTVNCL------CGAEFQLTSSCVDAESAGVI-- NC_001451_IBV_Beaudette_nsp2_529 ALDVRAQTLDEIFDPTEILWLQVAAKIHVSS-------MAMRR--LVGEVTAKVMDAL-- AY646283_IBV-partridge_Partridge ALNARAQTLEEIFGPTEVLWLQVASKLQVSA-------MAMRR--LVGEVTAKVMDAL-- AY641576_IBV-peafowl_Peafowl/GD/ TLDARAQTLDEIFDSTEILWLQVAAKIQVSA-------MAMRR--LVGEVTAKVMEAL-- NC_002645_HCoV-229E_inf-1_nsp2_6 ----GVSVWRVIALQSVDCFVASSTFVEEEHVNRMDTFCFNVRNSVTDECRLAMLGAEMT NC_005831_HCoV-NL63_AmsterdamI_n ----GVSLWRVTAVHSDGMFVASSSYDALLHRNSLDPFCFDVNTLLSNQLRLAFLGASVT NC_002306_TGEV_PUR46-MAD_nsp2_63 ----GVSIWKVIKTFTVDETVCTPGFEGELND----FIKPESKSLVACSVKRAFITGDID NC_003436_PEDV_CV777_nsp2_627..2 ----GLAFWRILKVQSKDDLACSGKFLEHHEEGFTDPCYFLNDSSLATKLKFDILSGKFS DQ811787_PRCV_ISU-1_nsp2_628..29 ----GVSIWKVIKTFTVDETVCTLGFEGELND----FIKPESKSLIACSVKRAFITGEID AY994055_FIPV_79-1146_nsp2_641.. ----NVSVWKVIKTFTVNETVCTTDFEGELND----FIRPESTSPVSCSIKRAFITGEVD NC_009657_BtCoV-G1_BtCoV/512/200 GTNLGWGVWRIAKVQSKDDVATSGNVLVDDPEDRLDPCYFGNDGPFATKFKFQLLANSFD EF203064_Bat-CoV-HKU2_HKU2/GD/43 ----GVSAWRVVKAYTVDKFVASSNFDEHNHVMSLDQCSFDNFSPISVALKFSLLRGNCC NC_005147_HCoV-OC43_OC43_nsp2_94 ---------------PVNPVLHTKSAAG--------------YGGFGCKDSFTLYGQTVV NC_006577_CoV-HKU1A_N1_nsp2_872. ---------------PENPVLFTNSTDTVNHD------------------SFNLYGYSVT AY884001_CoV-HKU1B_N2_nsp2_866.. ---------------PENPVLFTNSTDTVNPD------------------SFNLYGYSVT DQ339101_CoV-HKU1C_N5_nsp2_866.. ---------------PENPVLFTNSTDTVNPD------------------SFNLYGYSVT NC_003045_BCoV_BCoV-ENT_nsp2_949 ---------------PVNPVLHTKSAAG--------------YGGFGCKDSFTLYGQTVV NC_001846_MHV_MHV-A59_nsp2_951.. ---------------PEGGVLFTQSTDTVNRE------------------SFKLYGHAVV NC_007732_PHEV_VW572_nsp2_949..2 ---------------PVNPVLHTKSAAG--------------YGGFGCKDSFTLYGQTVV EF424621_AntelopeCoV_US/OH1/2003 ---------------PVNPVLHTKSAAG--------------YGGFGCKDSFTLYGQTVV EF424622_GiCoV_US/OH3-TC/2006_ns ---------------PVNPVLHTKSAAG--------------YGGFGCKDSFTLYGQTVV NC_004718_SARS-human_Tor2_nsp2_8 ---------------PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRC AY304488_SARS-civet_SZ16_nsp2_79 ---------------PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRC NC_009694_SARS-bat_HKU3-1_nsp2_8 ---------------PTNAVVKMPCPACQDPEVGPEHSVADYHNHSNIETRLRKGGRTKC AY545919_SARS-badger_CFB/SZ/94/0 ---------------PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRC NC_009019_Bat-CoV-HKU4_B04f ---------------PRNALFLANCPCANNGACS--HSAAQVYNILDGKACVEVGGKSFT NC_009020_Bat-CoV-HKU5_LMH3f ---------------RKNAVLLTTCPCNKDGECK--HTLPQLVSMMTDKCDVEVVGKTFI NC_009021_Bat-CoV-HKU9_BF_005I ---------------KPGCVMLLDKSPG---------------------MRLIPGNRTYV NC_001451_IBV_Beaudette_nsp2_529 --------------------------------------------GSNLSALFQIVKQQIA AY646283_IBV-partridge_Partridge --------------------------------------------GSKLSSLFQIVKQQIA AY641576_IBV-peafowl_Peafowl/GD/ --------------------------------------------GSNLSVLFQIVKQQIA NC_002645_HCoV-229E_inf-1_nsp2_6 SNVRRQVASGVIDISTGWFDVYDDIFAESKPWFVRKAEDIFGPCWSALASALKQLKVTTG NC_005831_HCoV-NL63_AmsterdamI_n EDVKFAASTGVIDISAGMFGLYDDILTNNKPWFVRKASGLFDAIWDAFVAAIKLVPTTTG NC_002306_TGEV_PUR46-MAD_nsp2_63 DAVHDCIITGKLDLSTNLFGNVGLLF-KKTPWFVQKCGALFVDAWKVVEELCGSLTLTYK NC_003436_PEDV_CV777_nsp2_627..2 DEVKQAIIAGHVVVGSALVDIVDDAL--GQPWFIRKLGDLASAPWEQLKAVVRGLGLLSD DQ811787_PRCV_ISU-1_nsp2_628..29 DAVHDCIITGKLDLSTNLFGNVGLLF-KKPPWFVQKCGALFVDAWKVVEELCGSLTLTYK AY994055_FIPV_79-1146_nsp2_641.. DAVHDCIIAGKLDLSTNLFGSANLLF-KKMPWFVQKCGAIFADAWKVVEELLCSLKLTYK NC_009657_BtCoV-G1_BtCoV/512/200 DEVKGAIVQGVVHVNTAICDVVKDIL--GLPWFVKKLGSLVTVMWDQFVAGVQSMKICTL EF203064_Bat-CoV-HKU2_HKU2/GD/43 DDVKVAVATGVIDIGLGVFDVNDTVF-ENVPWFVQKF-EFLKPAWDALKQAIINLGVTSK NC_005147_HCoV-OC43_OC43_nsp2_94 Y-FGGCVY---------WSPARN--------------------IWIPILKSS-------- NC_006577_CoV-HKU1A_N1_nsp2_872. P-FGSCIY---------WSPRPG--------------------LWIPIIKSS-------- AY884001_CoV-HKU1B_N2_nsp2_866.. P-FGSCIY---------WSPRPG--------------------LWIPIIKSS-------- DQ339101_CoV-HKU1C_N5_nsp2_866.. P-FGSCIY---------WSPRPG--------------------LWIPIIKSS-------- NC_003045_BCoV_BCoV-ENT_nsp2_949 Y-FGGCVY---------WSPARN--------------------IWIPILKSS-------- NC_001846_MHV_MHV-A59_nsp2_951.. P-FGSAVY---------WSPCPG--------------------MWLPVIWSS-------- NC_007732_PHEV_VW572_nsp2_949..2 Y-FGGCVY---------WSPARN--------------------IWIPILKSS-------- EF424621_AntelopeCoV_US/OH1/2003 Y-FGGCVY---------WSPARN--------------------IWIPILKSS-------- EF424622_GiCoV_US/OH3-TC/2006_ns Y-FGGCVY---------WSPARN--------------------IWIPILKSS-------- NC_004718_SARS-human_Tor2_nsp2_8 --FGGCVFA--------YVGCYNKRA-----------------YWVPRASAD-------- AY304488_SARS-civet_SZ16_nsp2_79 --FGGCVFA--------YVGCYNKRA-----------------YWVPRASAD-------- NC_009694_SARS-bat_HKU3-1_nsp2_8 --FGGCVFS--------YVGCYNKRA-----------------YWVPRASAN-------- AY545919_SARS-badger_CFB/SZ/94/0 --FGGCVFA--------YVGCYNKRA-----------------YWVPRASAD-------- NC_009019_Bat-CoV-HKU4_B04f LTFGGVVYA--------YMGCCDGTM-----------------YFVPRAKSC-------- NC_009020_Bat-CoV-HKU5_LMH3f LTYGGVIYA--------YMGCSGGTM-----------------HFIPRAKSC-------- NC_009021_Bat-CoV-HKU9_BF_005I S-FGGAIWS--------PIGKVNGVT-----------------VWVPRAYSI-------- NC_001451_IBV_Beaudette_nsp2_529 RIFQKALA---------IFENVNELP------------QRIAALKMAFAKCARSITVVVV AY646283_IBV-partridge_Partridge RIFQKALA---------IFEDVKDLP------------QRIAALQMAFAKCAKTITVVVV AY641576_IBV-peafowl_Peafowl/GD/ RIFQKALA---------IFENVSELP------------QRIAALKMAFAKCAKSITVVVV NC_002645_HCoV-229E_inf-1_nsp2_6 ELVRFVKSICNSAVAVVGGTIQILASVPEKFLNAFDVFVTAIQTVFDCAVETCTIAGKAF NC_005831_HCoV-NL63_AmsterdamI_n VLVRFVKSIASTVLTVSNGVIIMCADVPDAFQSVYRTFTQAICAAFDFSLDVFKIGDVKF NC_002306_TGEV_PUR46-MAD_nsp2_63 QIYEVVASLCTSAFTIVNYKPTFVV-PDNRVKDLVDKCVKVLVKAFDVFTQIITIAGIEA NC_003436_PEDV_CV777_nsp2_627..2 EVVLFGKRLSCATLSIVNGVFEFLADVPEKLAAAVTVFVNFLNEFFESACDCLKVGGKTF DQ811787_PRCV_ISU-1_nsp2_628..29 QIYEVVASLCNSVFTIVNYKPTFVV-PDNRVKDLVDKCVKVLVKAFDVFTQNIIIAGIEA AY994055_FIPV_79-1146_nsp2_641.. QIYDVVASLCTSAFTIMDYKPVFVV-SSNSVKDLVDKCVKILVKAFDVFTQTITIAGVEA NC_009657_BtCoV-G1_BtCoV/512/200 KVVQLAKALSCATMSVVKGVITLVAEVPEIFKRLFYTLTSALKSLCTSSCDALVVAGKSF EF203064_Bat-CoV-HKU2_HKU2/GD/43 AVLSFIKSLCSAAFSVVDGVPVIVCTVAERFSKAFTDFLSYTRECFTALCDDIVVFGVKC NC_005147_HCoV-OC43_OC43_nsp2_94 -----VKSYDSLVYTGVLGCKAIVKETNLICKALYLDYVQHKCG----NLHQRELLGVSD NC_006577_CoV-HKU1A_N1_nsp2_872. -----VKSYDDLVYSGVVGCKSIVKETALITHALYLDYVQCKCG----NLEQNHILGVNN AY884001_CoV-HKU1B_N2_nsp2_866.. -----VKSYDDLVYSGVVGCKSIVKETALITHALYLDYVQCKCG----NLEQNHILGVNN DQ339101_CoV-HKU1C_N5_nsp2_866.. -----VKSYDDLVYSGVVGCKSIVKETALITHALYLDYVQCKCG----NLEQNHILGVNN NC_003045_BCoV_BCoV-ENT_nsp2_949 -----VKSYDGLVYTGVVGCKAIVKETNLICKALYLDYVQHKCG----NLHQRELLGVSD NC_001846_MHV_MHV-A59_nsp2_951.. -----VKSYSGLTYTGVVGCKAIVQETDAICRSLYMDYVQHKCG----NLEQRAILGLDD NC_007732_PHEV_VW572_nsp2_949..2 -----VKSYDSLVYTGVVGCKAIVKETNLICKALYLDYVEHKCG----NLHQRELLGVSD EF424621_AntelopeCoV_US/OH1/2003 -----VKSYDGLVYTGVVGCKAIVKETNLICKALYLDYVQHKCG----NLHQRELLGVSD EF424622_GiCoV_US/OH3-TC/2006_ns -----VKSYDGLVYTGVVGCKAIVKETNLICKALYLDYVQHKCG----NLHQRELLGVSD NC_004718_SARS-human_Tor2_nsp2_8 ---------IGSGHTGITG---------DNVETLNEDLLEILSR---ERVNINIVGDFHL AY304488_SARS-civet_SZ16_nsp2_79 ---------IGSGHTGITG---------DNVETLNEDLLEILSR---ERVNINIVGDFHL NC_009694_SARS-bat_HKU3-1_nsp2_8 ---------IGANHTGITG---------ENVETLNEDLLEILNR---ERVNINIVGDFRF AY545919_SARS-badger_CFB/SZ/94/0 ---------IGSGHTGITG---------DNVETLNEDLLEILSR---ERVNINIVGDFHL NC_009019_Bat-CoV-HKU4_B04f -----VSRIGDAIFTGCTGTWDKVVETANLFLEKAQRSLNF------------------- NC_009020_Bat-CoV-HKU5_LMH3f -----VSKIGDAIFTGCTGTWSKVCETANLFLERAQHAINF------------------- NC_009021_Bat-CoV-HKU9_BF_005I ---------VAGEHSGAVGSGDTVAINKELVEYLIEGI----------RVDADTLDNPTC NC_001451_IBV_Beaudette_nsp2_529 ERTLVVKEFAGTCLASINGA------VAKFFEELPNGFMGSKIF---------------- AY646283_IBV-partridge_Partridge EKAIVVREFSGTCLASINGA------IAKFFAELPNGFMGSKVF---------------- AY641576_IBV-peafowl_Peafowl/GD/ ERTLVVREFAGTCLASINGA------VAKFFEELPNGFMGSKIF---------------- : NC_002645_HCoV-229E_inf-1_nsp2_6 DKV---FDYVLLDNALVKLVTTKLKGVRERGLNKVKYATVVVGSTEEVKSS-RVERSTAV NC_005831_HCoV-NL63_AmsterdamI_n KRL---GDYVLTENALVRLTTEVVRGVRDARIKKAMFTKVVVGPTTEVKFS-VIELATVN NC_002306_TGEV_PUR46-MAD_nsp2_63 KCFVLGAKYLLFNNALVKLVSVKILGKKQKGLECAFFATSLVGATVNVTPK-RTETATIS NC_003436_PEDV_CV777_nsp2_627..2 NKV---GSYVLFDNALVKLVKAKARGPRQAGICEVRYTSLVVGSTTKVVSK-RVENANVN DQ811787_PRCV_ISU-1_nsp2_628..29 KCFVLGAKYLLFNNALVKLVSVKILGKKQKGLECAFFATSLVGATANVTPT-RTETATIS AY994055_FIPV_79-1146_nsp2_641.. KCFVLGSKYLLFNNALVKLVSVKILGKRQKGLDSAFFATNLIGATVNVTPQ-RTESAYIS NC_009657_BtCoV-G1_BtCoV/512/200 AKI---GDYVLLPSALVRLVSSKVKGKAQSGIKQLQFATVVLGDTHKVESD-RVEFSSVN EF203064_Bat-CoV-HKU2_HKU2/GD/43 KAV---GDYIIFNNSVVKTVKAKIKGVKEAGLKTMTYTQCLLGPTKPVKVK-RVERSVAQ NC_005147_HCoV-OC43_OC43_nsp2_94 VW----HKQLLLNRGVYKPLLENIDYFNMRRAKFSLETFTVCADGFMPFLL--------- NC_006577_CoV-HKU1A_N1_nsp2_872. SW----CRQLLLNRGDYNMLLKNIDLFVKRRADFAC-KFAVCGDGFVPFLL--------- AY884001_CoV-HKU1B_N2_nsp2_866.. SW----CRQLLLNRGDYNMLLKNIDLFVKRRADFAC-KFAVCGDGFVPFLL--------- DQ339101_CoV-HKU1C_N5_nsp2_866.. SW----CRQLLLNRGDYNMLLKNIDLFVKRRADFAC-KFAVCGDGFVPFLL--------- NC_003045_BCoV_BCoV-ENT_nsp2_949 VW----HKQLLLNRGVYKPLLENIDYFNMRRAKFSLETFTVCADGFMPFLL--------- NC_001846_MHV_MHV-A59_nsp2_951.. VY----HRQLLVNRGDYSLLLENVDLFVKRRAEFAC-KFATCGDGLVPLLL--------- NC_007732_PHEV_VW572_nsp2_949..2 VW----HKQLLLNRGVYKPLLENIDYFNMRRAKFSLETFTVCADGFMPFLL--------- EF424621_AntelopeCoV_US/OH1/2003 VW----HKQLLLNRGVYKPLLENIDYFNMRRAKFSLETFTVCADGFMPFLL--------- EF424622_GiCoV_US/OH3-TC/2006_ns VW----HKQLLLNRGVYKPLLENIDYFNMRRAKFSLETFTVCADGFMPFLL--------- NC_004718_SARS-human_Tor2_nsp2_8 N-----EEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGK--PVKGAWN AY304488_SARS-civet_SZ16_nsp2_79 N-----EEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGK--PVKGAWN NC_009694_SARS-bat_HKU3-1_nsp2_8 N-----EEVAIILASFSASPSAFIETVKGLDYKSFKVIVESCGNYKVTNGK--PVTGAWN AY545919_SARS-badger_CFB/SZ/94/0 N-----EEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGK--PVKGAWN NC_009019_Bat-CoV-HKU4_B04f ------CQQFALTEVVLAILSGTTSTFEELR--------DLCHNASYEKVR--------- NC_009020_Bat-CoV-HKU5_LMH3f ------VNEFVLTETVVALLSGTTSSIEELR--------DLCRNATFEKVR--------- NC_009021_Bat-CoV-HKU9_BF_005I A-----TFIANLDCDTKAPVVHTVESLQGL-----------CLANKIMLGD--------- NC_001451_IBV_Beaudette_nsp2_529 ------TTLAFFKEAAVRVVENIPNAPRGTK------GFEVVGNAKGTQVVVRGMRNDLT AY646283_IBV-partridge_Partridge ------STLAFFKEAAVKIVENVPGAPQGTK------GFEVVGNAKGTQVVIRGMRNDLT AY641576_IBV-peafowl_Peafowl/GD/ ------TTLAFFKEAAVKIVENIPNAPRGTR------GFEVVGNAKGTQVVVRGMRNDLT NC_002645_HCoV-229E_inf-1_nsp2_6 LTIANNYSKLFDEGYTVVIGDVAYFVSDGYFRLMASPNSVLTTAVYKP------LFAFNV NC_005831_HCoV-NL63_AmsterdamI_n LRLVDCAPVVCPKGKIVVIAGQAFFYSGGFYRFMVDPTTVLNDPVFTG------DLFYTI NC_002306_TGEV_PUR46-MAD_nsp2_63 LNKVD-DVVAPGEGYIVIVGDMAFYKSGEYYFMMSSPNFVLTNNVFKAVKVPSYDIVYDV NC_003436_PEDV_CV777_nsp2_627..2 LVVVDEDVTLNTTGRTVVVDGLAFFESDGFYRHLADADVVIEHPVYKS------ACELKP DQ811787_PRCV_ISU-1_nsp2_628..29 LNKVD-DVVAPGEGYIVIVGDMAFYKSGEYYFMMSSPNSVLTNNVFKAVKVPSYDIVYDV AY994055_FIPV_79-1146_nsp2_641.. LNKVD-DVVTPGGGHIVIIGDMAFYKSEEYYFMMASPDSVLVNNVFKAARVPSYNIVYDV NC_009657_BtCoV-G1_BtCoV/512/200 LKMVDEEFPLNPVGHTVAVGNQAFFCSDGLYRFMADRDLVITSPIFKP------ELELEP EF203064_Bat-CoV-HKU2_HKU2/GD/43 LKVVDTAVPLKQEGECLVVGGRAMFRSDGYYRFMADADVVLESPVFTA------GSQYNV NC_005147_HCoV-OC43_OC43_nsp2_94 ------DDLVPRAYYLAVSG--------QAFCDYADK------------------LCHAV NC_006577_CoV-HKU1A_N1_nsp2_872. ------DGLIPRSYYLIQSG--------IFFTSLMSQ------------------FSQEV AY884001_CoV-HKU1B_N2_nsp2_866.. ------DGLIPRSYYLIQSG--------IFFTSLMSQ------------------FSQEV DQ339101_CoV-HKU1C_N5_nsp2_866.. ------DGLIPRSYYLIQSG--------IFFTSLMSQ------------------FSQEV NC_003045_BCoV_BCoV-ENT_nsp2_949 ------DDLVPRAYYLAVSG--------QAFCDYADK------------------ICHAV NC_001846_MHV_MHV-A59_nsp2_951.. ------DGLVPRSYYLIKSG--------QAFTSMMVN------------------FSHEV NC_007732_PHEV_VW572_nsp2_949..2 ------DDLVPRAYYLAVSG--------HAFCDYADK------------------LCHAV EF424621_AntelopeCoV_US/OH1/2003 ------DDLVPRAYYLAVSG--------QAFCDYADK------------------ICHAV EF424622_GiCoV_US/OH3-TC/2006_ns ------DDLVPRAYYLAVSG--------QAFCDYADK------------------ICHAV NC_004718_SARS-human_Tor2_nsp2_8 IGQQR-SVLTPLCGFPSQAA--------GVIRSIFARTL---------------DAANHS AY304488_SARS-civet_SZ16_nsp2_79 IGQQR-SVLTPLCGFPSQAA--------GVIRSIFSRTL---------------DAANHS NC_009694_SARS-bat_HKU3-1_nsp2_8 IGQQR-SILTPLCGFPSQAA--------GVIRSIFSRTL---------------DAANHS AY545919_SARS-badger_CFB/SZ/94/0 IGQQR-SVLTPLCGFPSQAA--------GVIRSIFARTL---------------DAANHS NC_009019_Bat-CoV-HKU4_B04f ------DHLVNH-GFVVTIG--------DYIRDA---------------------INIGA NC_009020_Bat-CoV-HKU5_LMH3f ------DYLTPR-GWIVTMG--------SYIEGV---------------------INVGA NC_009021_Bat-CoV-HKU9_BF_005I ------KPLPTDEFHPFIVG-----------------------------------LAYHV NC_001451_IBV_Beaudette_nsp2_529 LLDQKADIPVEPEGWSAILD--------GHLCYVFRSGDRFYAAPLSG------NFALSD AY646283_IBV-partridge_Partridge LLDQKAEIPVEPEGWSAIMD--------GHLCYVFKSGDRFYAAPLSG------NFALHD AY641576_IBV-peafowl_Peafowl/GD/ LLDQKAEIPVESEGWSAILG--------GHLCYVFKSGDRFYAAPLSG------NFALHD NC_002645_HCoV-229E_inf-1_nsp2_6 NVMGTRPEKFPTTVTC---ENLESAVLFVNDKITEF---QLDYSIDVIDNEIIVKPNI-S NC_005831_HCoV-NL63_AmsterdamI_n KFSGFKLDGFNHQFVTA--SSATDAIIAVELLLLDFKTAVFVYTCVVDGCSVIVRRDA-T NC_002306_TGEV_PUR46-MAD_nsp2_63 DNDTKSKMIAKLGSSFEYDGDIDAAIVKVNELLIEFRQQSLCFRAFKDDKSIFVEAYFKK NC_003436_PEDV_CV777_nsp2_627..2 VFECDPIPDFPLPVA----ASVAELCVQTDLLLKNYNTPYKTYSCVVRGDKCCITCTL-Q DQ811787_PRCV_ISU-1_nsp2_628..29 DNDTKSKMIAKLGSSFEYDGDIDAAIVKVNELLIEFRQQSLCFRALKDDKTIFVEAYFKK AY994055_FIPV_79-1146_nsp2_641.. NDDTKSKMVVKIGTSFDFDGDLDAAIAKVNDLLIEFRQEKLCFRALKDGENILVEAYLKK NC_009657_BtCoV-G1_BtCoV/512/200 IFECDAIPGFPKVAA----SNVAELCVKVDTLLFNYDKIYKKYSTIIKGDRCYIQCTH-T EF203064_Bat-CoV-HKU2_HKU2/GD/43 VFETDALFIAPEIGTVFEGDNIDTVVQTVANKVQAFNNRFVVYNAHVVDGAINVFCDY-K NC_005147_HCoV-OC43_OC43_nsp2_94 VSKSKELLDVSL-------DSLGAAIHYLNSKIVDL------AQHFSDFGTSFVSKIVHF NC_006577_CoV-HKU1A_N1_nsp2_872. SDMCLKMCILFM-------DRVSVATFYIEHYVNRL------VTQFKLLGTTLVNKMVNW AY884001_CoV-HKU1B_N2_nsp2_866.. SDMCLKMCILFM-------DRVSVATFYIEHYVNRL------VTQFKLLGTTLVNKMVNW DQ339101_CoV-HKU1C_N5_nsp2_866.. SDMCLKMCILFM-------DRVSVATFYIEHYVNRL------VTQFKLLGTTLVNKMVNW NC_003045_BCoV_BCoV-ENT_nsp2_949 VSKSKELLDVSL-------DSLSAAIHYLNSKIVDL------AQHFSDFGTSFVSKIVHF NC_001846_MHV_MHV-A59_nsp2_951.. TDMCMDMALLFM-------HDVKVATKYVKKVTGKL------AVRFKALGVAVVRKITEW NC_007732_PHEV_VW572_nsp2_949..2 VSKSKDLLDVSL-------DSLGAAIHYLNFKIVDL------AQHFSDFGASFVSTIVRY EF424621_AntelopeCoV_US/OH1/2003 VSKSKELLDVSL-------DSLSAAIYYLNSKIVDL------AQHFSDFGTSFVSKIVHF EF424622_GiCoV_US/OH3-TC/2006_ns VSKSKELLDVSL-------DSLSAAIYYLNSKIVDL------AQHFSDFGTSFVSKIVHF NC_004718_SARS-human_Tor2_nsp2_8 IPDLQRAAVTIL-------DGISEQSLRLVDAMV--------YTSDLLTNSVIIMAYV-- AY304488_SARS-civet_SZ16_nsp2_79 IPDLQRAAVTIL-------DGISEQSLRLVDAMV--------YTSDLLTNSVIIMAYV-- NC_009694_SARS-bat_HKU3-1_nsp2_8 ILDLQRAAVTTL-------DGISEQSLRLVDAMV--------YTSDLLTNSVVVMAYV-- AY545919_SARS-badger_CFB/SZ/94/0 IPDLQRAAVTIL-------DGISEQSLRLVDAMV--------YTSDLLTNSVIIMAYV-- NC_009019_Bat-CoV-HKU4_B04f NGVCNATINAPFIAF----TGLGESFKKVSAIPWKICSNLKSALDYYSSNIMF---RVFP NC_009020_Bat-CoV-HKU5_LMH3f AGVCNAALNAPFIVL----SGLGESFKKVAATPWKLCSSLRETLDHYADSITY---RVFP NC_009021_Bat-CoV-HKU9_BF_005I QRACWYGALASRTF-----EAFRDFVRTEEERFAQF----FGKVCAPINGCVY------- NC_001451_IBV_Beaudette_nsp2_529 VHCCERVVCLSDGVTPEINDGLILAAIYSSFSVSELVTALKKGEPFKFLGHKFVYAKD-- AY646283_IBV-partridge_Partridge VHCCERVVCLVDGVTPEINDGLILAAIYSSFSVSELVAALKKGEPFKFLGHKFVYAKE-- AY641576_IBV-peafowl_Peafowl/GD/ VHCCERVVCLSDGVTPEINDGLILAAIYSSFSVAELVAAIKRGEPFKFLGHKFVYAKD-- NC_002645_HCoV-229E_inf-1_nsp2_6 LCVPLYVRDYVDKWDDFCRQYSNESWFEDDYRAFISVLDITDAAV---KAAESKAFVDTI NC_005831_HCoV-NL63_AmsterdamI_n FATHVCFKDCYNVWEQFCIDNCGEPWFLTDYNAILQSNNPQCAIV---QASESKVLLERF NC_002306_TGEV_PUR46-MAD_nsp2_63 YKMPACLAKHIGLW-NIIKKDSCKRGFLNLFNHLNELEDIKETNI---------QAIKNI NC_003436_PEDV_CV777_nsp2_627..2 FKAPSYVEDAVN-FVDLCTKNIGTAGFHEFYITAHEQQDLQGFLTTCCTMSGFECFM-PT DQ811787_PRCV_ISU-1_nsp2_628..29 YKMPACLANHIGLW-NIIKKDSCKKGFLNLFNHLNELEDIKETNI---------QAIKNI AY994055_FIPV_79-1146_nsp2_641.. YKMPVCLKNHVGLW-DIIRQDSGKKGFLDTFNHLNELEDVKDIKI---------QTIKNI NC_009657_BtCoV-G1_BtCoV/512/200 FKAPSYYFDD-DEFVELCTKYYKLPDFDAFYNAVHAATDMDQF---CALCTSGFEVFIPR EF203064_Bat-CoV-HKU2_HKU2/GD/43 FICPAFLDGF-PEWFSFCKNHFKDAGFVEFYDCII--NSDSTFQTTFQPYLDLKPSVDAY NC_005147_HCoV-OC43_OC43_nsp2_94 FKTFTTSTALAFAWVLFHVLHGAYIVVESDI----------------------------- NC_006577_CoV-HKU1A_N1_nsp2_872. FNTMLDASAPATGWLLYQLLNGLFVVSQANF----------------------------- AY884001_CoV-HKU1B_N2_nsp2_866.. FNTMLDASAPATGWLLYQLLNGLFVVSQANF----------------------------- DQ339101_CoV-HKU1C_N5_nsp2_866.. FNTMLDASAPATGWLLYQLLNGFFVVSQANL----------------------------- NC_003045_BCoV_BCoV-ENT_nsp2_949 FKTFTTSTALAFAWVLFHVLHGAYIVVESDI----------------------------- NC_001846_MHV_MHV-A59_nsp2_951.. FDLAVDIAASAAGWLCYQLVNGLFAVANGVI----------------------------- NC_007732_PHEV_VW572_nsp2_949..2 FKTFTTSTALAFAWVLFHVLHGAYIVVESDI----------------------------- EF424621_AntelopeCoV_US/OH1/2003 FKTFTTSTALAFAWVLFHVLHGAYIVVESDI----------------------------- EF424622_GiCoV_US/OH3-TC/2006_ns FKTFTTSTALAFAWVLFHVLHGAYIVVESDI----------------------------- NC_004718_SARS-human_Tor2_nsp2_8 ---TGGLVQQTSQWLSNLLGTTVEK-------------------------------LRPI AY304488_SARS-civet_SZ16_nsp2_79 ---TGGLVQQTSQWLSNLLGTTVEK-------------------------------LRPI NC_009694_SARS-bat_HKU3-1_nsp2_8 ---TGGLVQQTMQWLSNMLGTAVDK-------------------------------LKPV AY545919_SARS-badger_CFB/SZ/94/0 ---TGGLVQQTSQWLSNLLGTTVEK-------------------------------LRPI NC_009019_Bat-CoV-HKU4_B04f YDIPCDVSNFVELLLDCGKLTVATSYFVLRY------LDEKFDTVLGTVSSACQTALSSF NC_009020_Bat-CoV-HKU5_LMH3f YDIPCDVTDYTALLLDCAVLTGASAYFVARY------VDEKVEQLTNLVFSSCQSAVAAF NC_009021_Bat-CoV-HKU9_BF_005I ---LAYTTGRVTLFSAYQVLNTAIAKSKDAF---------------GGVAAIVVDMLKPI NC_001451_IBV_Beaudette_nsp2_529 -AAVSFTLAKAATIADVLRLFQSARVIAEDVWSSFTEKSFEFWKLAYGKVRNLEEFVKTY AY646283_IBV-partridge_Partridge -AAVSFTLAKAATISDVLKLFQSARVETEDVWSALTEKSFEFWKLAYGKVRNLEEFVKTH AY641576_IBV-peafowl_Peafowl/GD/ -AAVSFTLAKAATIADVLKLFQSARVKVEDVWSSLTEKSFEFWRLAYGKVRNLEEFVKTY NC_002645_HCoV-229E_inf-1_nsp2_6 VPPCPSILKVIDGGKIWNGVIKNVNSVRDWLKSL--KLNLTQQGLLGTCAKRFKRWLGIL NC_005831_HCoV-NL63_AmsterdamI_n LPKCPEILLSIDDGHLWNLFVEKFNFVTDWLKTL--KLTLTSNGLLGNCAKRFRRVLVKL NC_002306_TGEV_PUR46-MAD_nsp2_63 L--CPDPLLDLDYGAIWYNCMPGC---SD--PSVLGSVQLLIGNGVKVVCDGCKGFANQL NC_003436_PEDV_CV777_nsp2_627..2 IPQCPAVLEEIDGGSIWRSFITGLNTMWDFCKRL--KVSFGLDGIVVTVARKFKRLGALL DQ811787_PRCV_ISU-1_nsp2_628..29 L--CPDPLLDLDYGAIWYNCMPSC---SD--SSVLGSVQLLIGNGVKVVCDGCKGFANQL AY994055_FIPV_79-1146_nsp2_641.. I--CPDLLLELDFGAIWYRCMPAC---SD--KSILGNVKIMLGNGVKVVCDGCHSFANRL NC_009657_BtCoV-G1_BtCoV/512/200 VPDCPPILNDIDGGSIWTSFILSVRSATDFIKTL--KIDLGLNGVVVFVTKKFRKAGALL EF203064_Bat-CoV-HKU2_HKU2/GD/43 L--GPEIVRAVDGGRLWRTVINGIGDAVNFCKNL--RLHFEFGELKGTVVKRFKGILGTL NC_005147_HCoV-OC43_OC43_nsp2_94 ------------------YFVKNI---PRYASAVAQAFQSVAKVVLDSLRVTFIDGL--- NC_006577_CoV-HKU1A_N1_nsp2_872. ------------------NFVALI---PDYAKILVNKFYTFFKLLLECVTVDVLKDM--- AY884001_CoV-HKU1B_N2_nsp2_866.. ------------------NFVALI---PDYAKILVNKFYTFFKLLLECVTVDVLKDM--- DQ339101_CoV-HKU1C_N5_nsp2_866.. ------------------NFVALI---PDYAKILVNKFYTFFKLLLECVTVDVLKDM--- NC_003045_BCoV_BCoV-ENT_nsp2_949 ------------------YFVKNI---PRYASAVAQAFRSVAKVVLDSLRVTFIDGL--- NC_001846_MHV_MHV-A59_nsp2_951.. ------------------TFVQEV---PELVKNFVDKFKAFFKVLIDSMSVSILSGL--- NC_007732_PHEV_VW572_nsp2_949..2 ------------------YFVKNI---PRYASAVAQAFRSVAKVVLDSLRVTFIDGL--- EF424621_AntelopeCoV_US/OH1/2003 ------------------YFVKNI---PRYASAVAQAFRSVAKVVLDSLRVTFIDGL--- EF424622_GiCoV_US/OH3-TC/2006_ns ------------------YFVKNI---PRYASAVAQAFRSVAKVVLDSLRVTFIDGL--- NC_004718_SARS-human_Tor2_nsp2_8 FEWIEAKL------SAGVEFLKDA---WEILKFLITGVFDIVKGQIQVASDNIKDCVKCF AY304488_SARS-civet_SZ16_nsp2_79 FEWIEAKL------SAGVEFLKDA---WEILKFLITGVFDIVKGQIQVASDNIKDCVKCF NC_009694_SARS-bat_HKU3-1_nsp2_8 FTWVEAKL------SAGVEFLRDA---WEILKFLITGVFDVIKGQIQVATDNIKECVKIF AY545919_SARS-badger_CFB/SZ/94/0 FEWIEAKL------SAGVEFLKDA---WEILKFLITGVFDIVKGQIQVASDNIKDCVKCF NC_009019_Bat-CoV-HKU4_B04f LNACVAAS------RATAGFINDM---FKLFKVLMHKLYVYTSCGYVAVAEHSSKIVQQV NC_009020_Bat-CoV-HKU5_LMH3f VQACMSTY------KATAKFISDM---FTLIKVVSERLYVYTSVGFVVVGDYSSQLLKQF NC_009021_Bat-CoV-HKU9_BF_005I LEWVLKKMSIAKG--AWLPYAEGL-------LALFKAQFTVVKGKFQFLRASLNSKCHSL NC_001451_IBV_Beaudette_nsp2_529 V--CKAQMSIV---ILAAVLGEDI---WHLVSQVIYKLGVLFTKVVDFCDKHWKGFCVQL AY646283_IBV-partridge_Partridge F--CKAQMSIV---VLAVVLGEGI---WHLVSQVIYRLGCSFSKVIDFCAKYWKGFCGQL AY641576_IBV-peafowl_Peafowl/GD/ F--CKAQMAIV---ILATVLGEGI---WHLVSQVIYKVGGLFTKVVDFCEKYWKGFCAQL . NC_002645_HCoV-229E_inf-1_nsp2_6 LE--------------AYNAFLDTVVSTVKIGGLTFKTYAF-DKPY--IVIRDIVCKVEN NC_005831_HCoV-NL63_AmsterdamI_n LD--------------VYNGFLETVCSVAYTAGVCIKYYAV-NVPY--VVISGFVSRVIR NC_002306_TGEV_PUR46-MAD_nsp2_63 SK--------------GYNKLCNAARNDIEIGGIPFSTFKTPTNTF--IEMTDAIYSVIE NC_003436_PEDV_CV777_nsp2_627..2 AE--------------MYNTYLSTVVENLVLAGVSFKYYAT-SVPK--IVLGGCFHSVKS DQ811787_PRCV_ISU-1_nsp2_628..29 SK--------------GYNKLCNAARNDIEIGGIPFSTFKTPTNTF--IEMTDAIYSVVE AY994055_FIPV_79-1146_nsp2_641.. TI--------------NYNKLCDTARKDIEIGGIPFSTFKTPSSSF--IDMKDAIYSVVE NC_009657_BtCoV-G1_BtCoV/512/200 QK--------------LYNAFLDTVTSFIKVAGVAFKYCAT-CVPK--IVINGCYHTVTR EF203064_Bat-CoV-HKU2_HKU2/GD/43 LT--------------VYNEFIQTTVSVLTICGISAKYYAF-DKPM--LCMHGITERVTS NC_005147_HCoV-OC43_OC43_nsp2_94 -------------------SCFKIGRRRICLSGRKIYEVERGLLHS--SQLPLDVYDLTM NC_006577_CoV-HKU1A_N1_nsp2_872. -------------------PVLKTINGLVCIVGNKFYNVSTGLIPG--FVLPCNAQEQ-- AY884001_CoV-HKU1B_N2_nsp2_866.. -------------------PVLKTINGLVCIVGNKFYNVSTGLIPG--FVLPCNAQEQ-- DQ339101_CoV-HKU1C_N5_nsp2_866.. -------------------PVLKTINGLVCIVGNKFYNVSTGLIPG--FVLPCNAQEQ-- NC_003045_BCoV_BCoV-ENT_nsp2_949 -------------------SCFKIGRRRICLSGSKIYEVERGLLHS--SQLPLDVYDLTM NC_001846_MHV_MHV-A59_nsp2_951.. -------------------TVVKTASNRVCLAGSKVYEVVQKSLSA--YVMPVGCSEATC NC_007732_PHEV_VW572_nsp2_949..2 -------------------SCFKIGRRRICLSGRKIYEVERGLLHS--SQLPLDVYDLTM EF424621_AntelopeCoV_US/OH1/2003 -------------------SCFKIGRRRICLSGSKIYEVERGLLHS--SQLPLDVYDLTM EF424622_GiCoV_US/OH3-TC/2006_ns -------------------SCFKIGRRRICLSGSKIYEVERGLLHS--SQLPLDVYDLTM NC_004718_SARS-human_Tor2_nsp2_8 ID--------------VVNKALEMCIDQVTIAGAKLRSLNLGEVF---IAQSKGLYRQCI AY304488_SARS-civet_SZ16_nsp2_79 ID--------------VVNKALEMCIDQVTIAGAKLRSLNLGEVF---IAQSKGLYRQCI NC_009694_SARS-bat_HKU3-1_nsp2_8 LG--------------VVNKALEMCLDQVTIAGTKLRALNLGEVF---IAQSRGLYRQCI AY545919_SARS-badger_CFB/SZ/94/0 ID--------------VVNKALEMCIDQVTIAGAKLRSLNLGEVF---IAQSKGLYRQCI NC_009019_Bat-CoV-HKU4_B04f LD--------------IMSKAMKLLHTNVSWAGTKLSAIIYEGREA--LLFNSGTYFCLS NC_009020_Bat-CoV-HKU5_LMH3f MH--------------ILSKAMQLLHTTVSWAGSKLPSVVYNGRDS--LVFPSGTYYCVS NC_009021_Bat-CoV-HKU9_BF_005I CD--------------LLTTIMSKLLTSVKWAGCKVDALYTGTYYY--FSRKGVLTEVQL NC_001451_IBV_Beaudette_nsp2_529 KRAKLIVTETFCVLKGVAQHCFQLLLDAIHSLYKSFKKCALGRIHGDLLFWKGGVHKIVQ AY646283_IBV-partridge_Partridge KKAKLLVTEHLCVLKGVAQHCFQLLLDAIHSMYKSFQKCALGRIHGDLLFWKGGVHKVVQ AY641576_IBV-peafowl_Peafowl/GD/ KRAKLIVTETLCVLKGVAQHCFQLLLDAIQFMYESFKKCALGRIHGDLLFWKGGVHKIIQ . NC_002645_HCoV-229E_inf-1_nsp2_6 KTEAEWIELFPHNDRIKSFSTFESAYMPIADPTHFDI----EEVEL-----LDAEFVEPG NC_005831_HCoV-NL63_AmsterdamI_n RERCDMT--FPCVSCVTFFYEFLDTCFGVSKPNAIDV----EHLEL-----KETVFVEPK NC_002306_TGEV_PUR46-MAD_nsp2_63 QGKAL---------------SFRDADVPVVDNGTISTADWSEPILL-----EPAEYVKPK NC_003436_PEDV_CV777_nsp2_627..2 VFASVFQ--IPVQAGIEKFKVFLNCVHPVV-PRVIET----SFVEL-----EETTF-KPP DQ811787_PRCV_ISU-1_nsp2_628..29 QGEAL---------------SFRDADVPVVDDGTIATVDWSEPILL-----EPAEYVKPK AY994055_FIPV_79-1146_nsp2_641.. YGEAL---------------SFKTASVPVTNSGIITTDDWSDPILL-----EPADYVEPK NC_009657_BtCoV-G1_BtCoV/512/200 LFAKDLQ--IPTEDGVADFNTFNHCVFPV-NPTRIET----DSLEL-----EEVDFVEPG EF203064_Bat-CoV-HKU2_HKU2/GD/43 FDITSLG--KPILDGLSRCNVFARGSNAVVVDS-VDH----ELLDL-----EECDFVEPA NC_005147_HCoV-OC43_OC43_nsp2_94 PSQVQKAKQKPI-------YLKGSGSDFSLADSVVEV----VTTSL-----TPCGYSEPP NC_006577_CoV-HKU1A_N1_nsp2_872. ----------------QIYFFEGVAESVIVEDDVIEN----VKSSL-----SSYEYCQPP AY884001_CoV-HKU1B_N2_nsp2_866.. ----------------QIYFFEGVAESVIVEDDVIEN----VKSSL-----SSYEYCQPP DQ339101_CoV-HKU1C_N5_nsp2_866.. ----------------QIYFFEGVAESVIVEDDVIEN----VKSSL-----SSYEYCQPP NC_003045_BCoV_BCoV-ENT_nsp2_949 PSQVQKAKQKPI-------YLKGSGSDFSLADSVVEV----VTTSL-----TPCGYSEPP NC_001846_MHV_MHV-A59_nsp2_951.. --------------------LVGEIEPAVFEDDVVDV----VKAPL-----TYQGCCKPP NC_007732_PHEV_VW572_nsp2_949..2 PSQVQKAKQKPI-------YLKGSGSDFSLADSVVEV----VTTSL-----TPCGYSEPP EF424621_AntelopeCoV_US/OH1/2003 PSQVQKAKQKPI-------YLKGSGTDFSLADSVVEV----VTTSL-----TPCGYSEPP EF424622_GiCoV_US/OH3-TC/2006_ns PSQVQKAKQKPI-------YLKGSGTDFSLADSVVEV----VTTSL-----TPCGYSEPP NC_004718_SARS-human_Tor2_nsp2_8 RGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVL----KNGELEALE-TPVDSFTNG AY304488_SARS-civet_SZ16_nsp2_79 RGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVL----KNGELEALE-TPVDSFTNG NC_009694_SARS-bat_HKU3-1_nsp2_8 RGKEQLQLLMPLKAPKEVTFLEGDAHDTVLTSEEVVL----KSGELEALE-TPIDSFTSG AY545919_SARS-badger_CFB/SZ/94/0 RGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVL----KNGELEALE-TPVDSFTNG NC_009019_Bat-CoV-HKU4_B04f TKAKTLQGQMNLVLPGDYNKKTLGILDPVPNADTIDVNANSTVVDVVHGQLEPTNEHGPS NC_009020_Bat-CoV-HKU5_LMH3f TQGRSLQDQFDLVIPGDLSKKQIGILEPTPNSTTVDKKINTNVVEVVVGQLEPTKEHSPE NC_009021_Bat-CoV-HKU9_BF_005I CAKRLGLLLTPKQQKMEVEVLDGDFDAPVTLTD-LELEECTGVLE------EVFGASDVK NC_001451_IBV_Beaudette_nsp2_529 DGDEIWFDAIDSVDVED---------LGVVQEKSIDF----EVCDD-----VTLPENQPG AY646283_IBV-partridge_Partridge EGDEIWFDAIDSIDVEE---------LGVIQEKPVDF----EVCDG-----IILPENQPG AY641576_IBV-peafowl_Peafowl/GD/ EGDEIWFDAIDSIDVED---------LGVVQEKLIDF----DVCDN-----VTLPENQPG . NC_002645_HCoV-229E_inf-1_nsp2_6 -CGGILAVIDEHVFYKKDGV----YYPSNGTN-ILPVA---FTKAAG NC_005831_HCoV-NL63_AmsterdamI_n -DGGQFFVSGDYLWYVVDDI----YYPASCNG-VLPVA---FTKLAG NC_002306_TGEV_PUR46-MAD_nsp2_63 -NNGNVIVIAGYTFYKDEDEH---FYPY-GFGKIVQRM---YNKMGG NC_003436_PEDV_CV777_nsp2_627..2 ALNGGIAIVDGFAFYYDGTL----YYPTDGNS-VVPIC---FKKKGG DQ811787_PRCV_ISU-1_nsp2_628..29 -NNGNVIVIAGYTFYKDEDEH---FYPY-GFGKIVQRM---YNKMGG AY994055_FIPV_79-1146_nsp2_641.. -DNGDVIVIAGYTFYKDEDDH---FYPY-GSGMVVQKM---YNKMGG NC_009657_BtCoV-G1_BtCoV/512/200 -VDGKLVILDDYSFYSDGTN----YYPSDGKG-VVASC---FKKKGG EF203064_Bat-CoV-HKU2_HKU2/GD/43 -SHGVLVVSDDYGFYSCETG----IYPYASDGKVLPLR---FRKKAG NC_005147_HCoV-OC43_OC43_nsp2_94 KVADKICIVDNVYMAKAGDK----YYPVVVDD-HVGLLDQAWRVPCA NC_006577_CoV-HKU1A_N1_nsp2_872. KSVEKICIIDNMYMGKCGDK----FFPIVMNDKNICLLDQAWRFPCA AY884001_CoV-HKU1B_N2_nsp2_866.. KSVEKICIIDNMYMGKCGDK----FFPIVMNDKNICLLDQAWRFPCA DQ339101_CoV-HKU1C_N5_nsp2_866.. KSVEKICIIDNMYMGKCGDK----FFPIVMNDKNICLLDHAWRFPCA NC_003045_BCoV_BCoV-ENT_nsp2_949 KVADKICIVDNVYMAKAGDK----YYPVVVDG-HVGLLDQAWRVPCA NC_001846_MHV_MHV-A59_nsp2_951.. TSFEKICIVDKLYMAKCGDQ----FYPVVVDNDTVGVLDQCWRFPCA NC_007732_PHEV_VW572_nsp2_949..2 KFADKICIVDNVYMAKAGDK----YYPVVVDD-HVGLLDQAWRVPCA EF424621_AntelopeCoV_US/OH1/2003 KVADKICIVDNVYMAKAGDK----YYPVVVDG-HVGLLDQAWRVPCA EF424622_GiCoV_US/OH3-TC/2006_ns KVADKICIVDNVYMAKAGDK----YYPVVVDG-HVGLLDQAWRVPCA NC_004718_SARS-human_Tor2_nsp2_8 AIVGTPVCVNGLMLLEIKDKE---QYCALSPG--LLATNNVFRLKGG AY304488_SARS-civet_SZ16_nsp2_79 AIVGTPVCVNGLMLLEIKDKE---QYCALSPG--LLATNNVFRLKGG NC_009694_SARS-bat_HKU3-1_nsp2_8 AVVGTPVCINGLMLLELENKE---QYCALSPG--LLATNNVFRLKGG AY545919_SARS-badger_CFB/SZ/94/0 AIVGIPVCVNGLMLLEIKDKE---QYCALSPG--LLATNNVFRLKGG NC_009019_Bat-CoV-HKU4_B04f MIVGNYVLVSDKLFVRTEDEE---FYPLCTNGKVVSTL---FRLKGG NC_009020_Bat-CoV-HKU5_LMH3f LVVGDYVIISNKIFVRSVEDSETVFYPLCTDGKIVPTL---FRLKGG NC_009021_Bat-CoV-HKU9_BF_005I LVKGTLVSLASKLFVRTEDGF---LYRYVKSGGVLGKA---FRLRGG NC_001451_IBV_Beaudette_nsp2_529 HMVQIEDDGKNYMFFRFKKDENIYYTPMSQLGAINVVC------KAG AY646283_IBV-partridge_Partridge HMVQFEDDGKNYMFFRFKREDNVYYTPMSQLGAINVVC------KAG AY641576_IBV-peafowl_Peafowl/GD/ HMVQIEDDGKNYMFFRFKKDENIYYTPMSQLGAINVVC------KAG . .